Recent ecological research has revealed that environmental factors can strongly affect insect immunity and influence the outcome of host–parasite interactions. To date, however, most studies examining immune function in mosquitoes have ignored environmental variability. We argue that one such environmental variable, temperature, influences both vector immunity and the parasite itself. As temperatures in the field can vary greatly from the ambient temperature in the laboratory, it will be essential to take temperature into account when studying vector immunology.
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The authors thank members of the Thomas, Read and Julian F. Hillyer laboratory groups for discussion, and D. Kroczynski and J. Teeple for insectary support. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institute of General Medical Sciences, the US National Institute of Allergy and Infectious Diseases or the US National Institutes of Health (NIH). Work in the authors' laboratories is funded, in part, by a grant from the US Pennsylvania Department of Health using Tobacco Settlement Funds. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions. Work in the authors' laboratories was also funded by the following: the US National Science Foundation (NSF)–NIH Ecology of Infectious Diseases programme (grant EF-0914384) and the NIH R21 programme (grant AI096036-01).
The authors declare no competing financial interests.
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Murdock, C., Paaijmans, K., Cox-Foster, D. et al. Rethinking vector immunology: the role of environmental temperature in shaping resistance. Nat Rev Microbiol 10, 869–876 (2012). https://doi.org/10.1038/nrmicro2900
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