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Tackling antibiotic resistance

Abstract

The development and spread of antibiotic resistance in bacteria is a universal threat to both humans and animals that is generally not preventable but can nevertheless be controlled, and it must be tackled in the most effective ways possible. To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011. From these discussions there emerged a priority list of steps that need to be taken to resolve this global crisis.

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References

  1. 1

    European Centre for Disease Prevention and Control (ECDC) & European Medicines Agency (EMEA). Joint technical report: the bacterial challenge. Time to react (ECDC–EMEA, Stockholm, 2009).

  2. 2

    Roberts, R. et al. Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship. Clin. Inf. Dis. 49, 1175–1184 (2009).

    Article  Google Scholar 

  3. 3

    Lecky, D. M. et al. Development of an educational resource on microbes, hygiene and prudent antibiotic use for junior and senior school children. J. Antimicrob. Chemother. 66 (Suppl. 5), v23–v31 (2011).

    CAS  Article  PubMed  Google Scholar 

  4. 4

    Tally, F. P. & DeBruin, M. F. Development of daptomycin for Gram-positive infections. J. Antimicrob. Chemother. 46, 523–526 (2003).

    Article  Google Scholar 

  5. 5

    Alekshun, M. & Levy S. B. Targeting virulence to prevent infection: to kill or not to kill? Drug Discov. Today Ther. Strateg. 1, 483–489 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L. & Gordon, J. I. Human nutrition, the gut microbiome and the immune system. Nature 474, 327–336 (2011).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7

    Gilbert, D. N. et al. The 10 X '20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin. Infect. Dis. 50, 1081–1083 (2010).

    Article  Google Scholar 

  8. 8

    Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenge of antibacterial discovery. Nature Rev. Drug Discov. 6, 29–40 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Blunt, J. W., Copp, B. R., Munro, M. H., Northcote, P. T. & Prinsep, M. R. Marine natural products. Nat. Prod. Rep. 28, 196–268 (2011).

    CAS  Article  PubMed  Google Scholar 

  10. 10

    Culliton, B. J. Emerging viruses, emerging threats. Science 247, 279–280 (1990).

    CAS  Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank J.D.W. for initiating and supporting this workshop.

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Correspondence to Julian Davies.

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The authors declare no competing financial interests.

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Bush, K., Courvalin, P., Dantas, G. et al. Tackling antibiotic resistance. Nat Rev Microbiol 9, 894–896 (2011). https://doi.org/10.1038/nrmicro2693

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