The development and spread of antibiotic resistance in bacteria is a universal threat to both humans and animals that is generally not preventable but can nevertheless be controlled, and it must be tackled in the most effective ways possible. To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011. From these discussions there emerged a priority list of steps that need to be taken to resolve this global crisis.
Subscribe to Journal
Get full journal access for 1 year
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
European Centre for Disease Prevention and Control (ECDC) & European Medicines Agency (EMEA). Joint technical report: the bacterial challenge. Time to react (ECDC–EMEA, Stockholm, 2009).
Roberts, R. et al. Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship. Clin. Inf. Dis. 49, 1175–1184 (2009).
Lecky, D. M. et al. Development of an educational resource on microbes, hygiene and prudent antibiotic use for junior and senior school children. J. Antimicrob. Chemother. 66 (Suppl. 5), v23–v31 (2011).
Tally, F. P. & DeBruin, M. F. Development of daptomycin for Gram-positive infections. J. Antimicrob. Chemother. 46, 523–526 (2003).
Alekshun, M. & Levy S. B. Targeting virulence to prevent infection: to kill or not to kill? Drug Discov. Today Ther. Strateg. 1, 483–489 (2004).
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L. & Gordon, J. I. Human nutrition, the gut microbiome and the immune system. Nature 474, 327–336 (2011).
Gilbert, D. N. et al. The 10 X '20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin. Infect. Dis. 50, 1081–1083 (2010).
Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenge of antibacterial discovery. Nature Rev. Drug Discov. 6, 29–40 (2007).
Blunt, J. W., Copp, B. R., Munro, M. H., Northcote, P. T. & Prinsep, M. R. Marine natural products. Nat. Prod. Rep. 28, 196–268 (2011).
Culliton, B. J. Emerging viruses, emerging threats. Science 247, 279–280 (1990).
We thank J.D.W. for initiating and supporting this workshop.
The authors declare no competing financial interests.
About this article
Cite this article
Bush, K., Courvalin, P., Dantas, G. et al. Tackling antibiotic resistance. Nat Rev Microbiol 9, 894–896 (2011). https://doi.org/10.1038/nrmicro2693
Antibacterial activity and biocompatibility of curcumin/TiO2 nanotube array system on Ti6Al4V bone implants
Materials Technology (2021)
Cellular and Molecular Life Sciences (2021)
Journal of Materials Science (2021)
Frontiers in Chemistry (2021)
Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation
PLOS ONE (2021)