Integrative and conjugative elements (ICEs) are being identified in increasing numbers. Although some of the elements now classified as ICEs were discovered a long time ago, such as pSAM2 (1984) and Tn916 (1995), the similarities between these elements have only recently been recognized. ICEs can allow bacteria to survive in new environments and acquire virulence factors, and can have profound effects on the bacterial genome.
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BMC Microbiology (2011)