Plasmodium genomics: latest milestone

Article metrics


Our knowledge on comparative genomics of the malaria parasites has advanced a step forward with the publication of the genomes of two primate-infecting malaria parasites: Plasmodium vivax and Plasmodium knowlesi. Even though the genomes of these organisms are the fifth and sixth Plasmodium genomes to be sequenced, respectively, both have revealed previously unknown features, which are discussed in this month's Genome Watch.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Diagram of the malaria parasite's life cycle.


  1. 1

    Carlton, J. M. et al. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 455, 757–763 (2008).

  2. 2

    Pain, A. et al. The genome of the simian and human malaria parasite Plasmodium knowlesi. Nature 455, 799–803 (2008).

  3. 3

    Carlton, J. M. et al. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 419, 512–519 (2002).

  4. 4

    Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498–511 (2002).

  5. 5

    Hall, N. et al. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science 307, 82–86 (2005).

  6. 6

    Brown, K. N. & Brown, I. N. Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature 208, 1286–1288 (1965).

  7. 7

    Marti, M., Good, R. T., Rug, M., Knuepfer, E. & Cowman, A. F. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science 306, 1930–1933 (2004).

  8. 8

    Jeffares, D. C. et al. Genome variation and evolution of the malaria parasite Plasmodium falciparum. Nature Genet. 39, 120–125 (2007).

  9. 9

    Volkman, S. K. et al. A genome-wide map of diversity in Plasmodium falciparum. Nature Genet. 39, 113–119 (2007).

  10. 10

    A global network for investigating the genomic epidemiology of malaria. Nature 456, 732–737 (2008).

  11. 11

    Winzeler, E. A. et al. Malaria research in the post-genomic era. Nature 455, 751–756 (2008).

Download references

Author information

Related links

Related links


Plasmodium falciparum

Plasmodium knowlesi

Plasmodium vivax

Rights and permissions

Reprints and Permissions

About this article

Further reading