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A dynamic view of the spread and intracellular distribution of Salmonella enterica

Nature Reviews Microbiology volume 7, pages 73–80 (2009)Cite this article

Abstract

The events that determine the dynamics of proliferation, spread and distribution of microbial pathogens within their hosts are surprisingly heterogeneous and poorly understood. We contend that understanding these phenomena at a sophisticated level with the help of mathematical models is a prerequisite for the development of truly novel, targeted preventative measures and drug regimes. We describe here recent studies of Salmonella enterica infections in mice which suggest that bacteria resist the antimicrobial environment inside host cells and spread to new sites, where infection foci develop, and thus avoid local escalation of the adaptive immune response. We further describe implications for our understanding of the pathogenic mechanism inside the host.

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Figure 1: Spread of Salmonella enterica in the mouse.
Figure 2: Population dynamics of Salmonella enterica in the organs of infected mice.
Figure 3: The key immunological factors that control the intracellular and extracellular phases of infection.

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Acknowledgements

This work was supported by grants from the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, the Medical Research Council and the Royal Society.

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Author notes

  1. Pietro Mastroeni and Andrew Grant: P.M. and A.G. contributed equally to this work.

Authors and Affiliations

  1. Olivier Restif and Duncan Maskell are at the Department of Veterinary Medicine, Pietro Mastroeni, Andrew Grant, University of Cambridge, Madingley Road, Cambridge, CB3 OES, United Kingdom.,

    Pietro Mastroeni, Andrew Grant, Olivier Restif & Duncan Maskell

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  1. Pietro Mastroeni
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Correspondence to Pietro Mastroeni.

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Mastroeni, P., Grant, A., Restif, O. et al. A dynamic view of the spread and intracellular distribution of Salmonella enterica. Nat Rev Microbiol 7, 73–80 (2009). https://doi.org/10.1038/nrmicro2034

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