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Ibis T5000: a universal biosensor approach for microbiology

Nature Reviews Microbiology volume 6, pages 553558 (2008) | Download Citation

Abstract

We describe a new technology, the Ibis T5000, for the identification of pathogens in clinical and environmental samples. The Ibis T5000 couples nucleic acid amplification to high-performance electrospray ionization mass spectrometry and base-composition analysis. The system enables the identification and quantification of a broad set of pathogens, including all known bacteria, all major groups of pathogenic fungi and the major families of viruses that cause disease in humans and animals, along with the detection of virulence factors and antibiotic resistance markers.

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Acknowledgements

The authors acknowledge the government agencies that supported the development of the Ibis T5000 universal biosensor technology, including the Defense Advanced Research Projects Agency (DARPA), the Centers for Disease Control and Prevention, the National Institutes of Health and the Department of Homeland Security.

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Affiliations

  1. Ibis Biosciences, 1896 Rutherford Road, Carlsbad, California 92008, USA.

    • David J. Ecker
    • , Rangarajan Sampath
    • , Christian Massire
    • , Lawrence B. Blyn
    • , Thomas A. Hall
    • , Mark W. Eshoo
    •  & Steven A. Hofstadler

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Competing interests

The authors are employees of Ibis Biosciences.

Corresponding author

Correspondence to David J. Ecker.

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DOI

https://doi.org/10.1038/nrmicro1918

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