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Single-cell genomics

Abstract

Efforts to describe and functionally categorize the amazing diversity of microbial life have long been hampered by our inability to cultivate most microorganisms in the laboratory. Recent technological advances in whole-genome amplification and cell sorting now permit insights into previously uncharacterized microorganisms, without prior cultivation. This month's Genome Watch reviews a selection of the initial attempts to exploit these important advances.

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Figure 1: Overview of the principle of multiple displacement amplification.

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Entrez Genome

Escherichia coli

Prochlorococcus marinus

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Walker, A., Parkhill, J. Single-cell genomics. Nat Rev Microbiol 6, 176–177 (2008). https://doi.org/10.1038/nrmicro1862

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