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The rise of computational biology


The year 2001 saw a remarkable burst of interest in biological simulation, with several international meetings on the subject, and the inclusion, by journals, of web site references from which published models can be downloaded. So, why has all this happened so suddenly?

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Figure 1: Levels of modelling.
Figure 2: A model of the human torso used to reconstruct the electrical field changes that create the electrocardiogram (ECG).
Figure 3: Towards a theoretical biology?


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Work in the author's laboratory is supported by the British Heart Foundation, Medical Research Council, Wellcome Trust and Physiome Sciences. D.N. was a scientific founder of Physiome Sciences, Inc.; however, the company's contibution to the funding of research in his laboratory is less than 5%. Most of the laboratory's funds come from the British Heart Foundation, the Medical Research Council, the Royal Society and the Wellcome Trust. The work of D.N.'s research group is all in the public domain.

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Brugada syndrome





Alliance for Cellular Signaling

Cardiac Mechanics Research Group


Entelos, Inc.

Gene Ontology Consortium

IBM's Blue Gene Project

Luo-Rudy dynamics model of the mammalian ventricular action potential

Pharsight Corporation

Physiome Sciences, Inc.

Simulations Plus, Inc.

Systems Biology

The Human Physiome Project

The Physiome Markup Languages

The Physiome Project

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Noble, D. The rise of computational biology. Nat Rev Mol Cell Biol 3, 459–463 (2002).

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