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Chromatin

Limiting the DDR

Nature Reviews Molecular Cell Biology volume 14, pages 464–465 (2013)Cite this article

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Now, Floyd et al. describe a mechanism by which a bromodomain-containing protein attenuates the DDR by promoting chromatin compaction.

BRD4 isoform B recruits the condensin II complex to remodel acetylated chromatin

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References

  1. Floyd, S. R. et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 498, 246–250 (2013)

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  1. Andrea Du Toit
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Du Toit, A. Limiting the DDR. Nat Rev Mol Cell Biol 14, 464–465 (2013). https://doi.org/10.1038/nrm3617

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