Classical cadherin adhesion receptors influence tissue integrity in health and disease. Their biological function is intimately linked to the actin cytoskeleton. To date, research has largely focused on identifying the molecular mechanisms that physically couple cadherin to cortical actin filaments. However, the junctional cytoskeleton is dynamic. Recent developments in understanding how filament dynamics and organization in the junctional cytoskeleton are controlled provide new insights into how the actin cytoskeleton regulates cadherin junctions in health and disease.
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The authors thank B. Brieher, M. Way, R. Parton and all their colleagues in the laboratory for many stimulating conversations, and the anonymous reviewers for thoughtful suggestions. A.S.Y. is supported by grants (APP1010489) and a Research Fellowship (631383) from the National Health and Medical Research Council of Australia, Australian Research Council (DP 0988935) and Kids Cancer Project of the Oncology Children's Foundation. A.R. was supported by a grant from the Human Frontiers Science Program.
The authors declare no competing financial interests.
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Ratheesh, A., Yap, A. A bigger picture: classical cadherins and the dynamic actin cytoskeleton. Nat Rev Mol Cell Biol 13, 673–679 (2012). https://doi.org/10.1038/nrm3431
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