Satellite cells are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle. The transcription factors paired-box 3 (PAX3) and PAX7 have essential and overlapping roles in myogenesis. PAX3 acts to specify embryonic muscle precursors, whereas PAX7 enforces the satellite cell myogenic programme while maintaining the undifferentiated state. Recent experiments have suggested that PAX7 is dispensable in adult satellite cells. However, these findings are controversial, and the issue remains unresolved.
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We thank F. Bentzinger and H. Yin for critical reading of the manuscript. Y.X.W. is supported by a fellowship from the Ontario Research Fund and by the Canadian Institutes of Health Research (CIHR) Training Program in Regenerative Medicine. M.A.R. holds the Canada Research Chair in Molecular Genetics and is an International Research Scholar of the Howard Hughes Medical Institute. The work from the laboratory of M.A.R. is supported by grants from the US National Institutes of Health, the Howard Hughes Medical Institute, the CIHR, the Muscular Dystrophy Association and the Canada Research Chair Program.
The authors declare no competing financial interests.
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Wang, Y., Rudnicki, M. Satellite cells, the engines of muscle repair. Nat Rev Mol Cell Biol 13, 127–133 (2012). https://doi.org/10.1038/nrm3265
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