With regard to our recent Opinion article (Computational morphodynamics of plants: integrating development over space and time. Nature Rev. Mol. Cell Biol. 12, 265–273 (2011))1, we thank Álvarez-Buylla and colleagues for their correspondence (Mutually reinforcing patterning mechanisms. Nature Rev. Mol. Cell Biol. 23 Jun 2011 (doi:10.1038/nrm3079-c1))2 and for letting us know of the addition that they have made (of a redundant WEREWOLF (WER) activating factor, MYB23)3 to their model of epidermal pattern formation in response to the experimental evidence on WER expression discussed by Savage et al.4. This underlines a central point of our article: that iteration between computational models and experimental tests can lead to new or modified models that better predict experimental results.
References
Roeder, A. H. et al. Computational morphodynamics of plants: integrating development over space and time. Nature Rev. Mol. Cell Biol. 12, 265–273 (2011).
Álvarez-Buylla, E., Benítez M. & Espinosa-Soto, C. Mutually reinforcing patterning mechanisms. Nature Rev. Mol. Cell Biol. 23 Jun 2011 (doi:10.1038/nrm3079-c1).
Benítez, M., Espinosa-Soto, C., Padilla-Longoria, P. & Alvarez-Buylla, E. R. Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model. BMC Syst. Biol. 2, 98 (2008).
Savage, N. S. et al. A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis. PLoS Biol. 6, e235 (2008).
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Roeder, A., Tarr, P., Tobin, C. et al. Mutually reinforcing patterning mechanisms: authors' reply. Nat Rev Mol Cell Biol 12, 533 (2011). https://doi.org/10.1038/nrm3079-c2
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DOI: https://doi.org/10.1038/nrm3079-c2
