Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.
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Landscape of submitochondrial protein distribution
Nature Communications Open Access 18 August 2017
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The authors declare no competing financial interests.
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Mick, D., Fox, T. & Rehling, P. Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat Rev Mol Cell Biol 12, 14–20 (2011). https://doi.org/10.1038/nrm3029
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