Abstract
The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles.
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Acknowledgements
Work in the G.W.G. laboratory is supported by grants from the Wellcome Trust and the Biotechnology and Biological Sciences Research Council, Cancer Research UK and the Association for International Cancer Research. G.W.G. thanks C. Isacke and N. Bryant for helpful comments on the manuscript.
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Gould, G., Lippincott-Schwartz, J. New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nat Rev Mol Cell Biol 10, 287–292 (2009). https://doi.org/10.1038/nrm2652
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DOI: https://doi.org/10.1038/nrm2652
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