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Cell polarity

Persistently on PAR

Nature Reviews Molecular Cell Biology volume 8, pages 852–853 (2007)Cite this article

The authors observed that migrating TIAM1−/− keratinocytes lost the front–rear polarity that is typical of wild-type (WT) cells, and although motility per se was unaffected, mutant cells showed an altered pattern of migration. TIAM1−/− cells changed direction frequently and migrated in a less linear (persistent) way than WT cells. Exposure to a gradient of epidermal growth factor substantially increased the migration of WT keratinocytes but had no effect on TIAM1-knockout cells, suggesting that TIAM1 is required both for persistent and chemotactic epithelial cell migration.

...the PAR–TIAM1 complex controls front–rear polarity and persistence...

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References

ORIGINAL RESEARCH PAPER

  1. Pegtel, D. M. et al. The Par–Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front–rear polarity. Curr. Biol. 6 Sept 2007 (doi:10.1016/j.cub.2007.08.035)

FURTHER READING

  1. Mertens, A. E. E. et al. Tiam1 takes PARt in cell polarity. Trends Cell Biol. 16, 308–316 (2006)

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Authors and Affiliations

  1. Editor, Cell Migration Gateway,

    Kim Baumann

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  1. Kim Baumann
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Baumann, K. Persistently on PAR. Nat Rev Mol Cell Biol 8, 852–853 (2007). https://doi.org/10.1038/nrm2283

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  • DOI: https://doi.org/10.1038/nrm2283

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