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Back to the future: education for systems-level biologists

Abstract

We describe a graduate course in quantitative biology that is based on original path-breaking papers in diverse areas of biology; each of these papers depends on quantitative reasoning and theory as well as experiment. Close reading and discussion of these papers allows students with backgrounds in physics, computational sciences or biology to learn essential ideas and to communicate in the languages of disciplines other than their own.

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Correspondence to David Botstein.

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Glossary

Croonian Lecture

The Croonian Lectures are prestigious lectureships given at the invitation of the Royal Society and the Royal College of Physicians.

Diauxic growth

In a medium that contains glucose and a less preferred carbon source, bacteria exhaust the glucose before consuming the other carbon source. Monod called this behaviour diauxie ('double growth' in French).

Hodgkin–Huxley equations

Hodgkin and Huxley published a series of (now classic) papers in 1952 on electrical activity and transmembrane ion currents in the squid giant axon. In these papers, they derived the Hodgkin–Huxley equations, which accurately describe the action potential.

Jackpot

In a series of parallel cultures, the Luria–Delbrück 'jackpot' is the rare observation of a large clone of mutant cells that are derived from a single mutational event early in the growth of the culture. Though rare, these jackpots occur much more frequently than the probability p(n) that is expected from simple Poisson statistics.

Poisson distribution

This distribution, p(n) = exp(-λ)λn/n!, gives the probability of observing n rare random events in a very large population, for which λ is the average expected number of these rare events.

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Wingreen, N., Botstein, D. Back to the future: education for systems-level biologists. Nat Rev Mol Cell Biol 7, 829–832 (2006). https://doi.org/10.1038/nrm2023

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