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Mechanisms of disease

VAV proteins get busy

Nature Reviews Molecular Cell Biology volume 7, pages 550–551 (2006)Cite this article

Now, the role of VAV proteins is expanding, as two reports show that these proteins also have important functions in other tissues.

The three members of the VAV family (VAV1–3) are guanine nucleotide-exchange factors (GEFs) for Rho-family GTPases, and they have similar regulatory and catalytic properties. By modulating the activities of Rho and Rac, they regulate the organization of the cytoskeleton. Despite the widespread localization of VAV2 and VAV3 in mouse tissues, most studies have focused on VAV function in the immune system.

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ORIGINAL RESEARCH PAPERS

  1. Sauzeau, V. et al. Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Nature Med. 11 June 2006 (doi:10.1038/nm1426)

  2. Hunter, S. G. et al. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol. Cell. Biol. 26, 4830–4842 (2006)

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  1. Ekat Kritikou
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Kritikou, E. VAV proteins get busy. Nat Rev Mol Cell Biol 7, 550–551 (2006). https://doi.org/10.1038/nrm1996

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