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Chromatin in pluripotent embryonic stem cells and differentiation

Nature Reviews Molecular Cell Biology volume 7, pages 540–546 (2006)Cite this article

Abstract

Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.

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Figure 1: Nuclear architecture in ES cells and differentiating ES-derived cells.
Figure 2: Chromatin during ES-cell differentiation.
Figure 3: Models of the transcriptional landscape during ES-cell differentiation.

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Acknowledgements

We thank M. Bustin, N. Dillon, P. Scaffidi and T. Takizawa for constructive comments. T.M. is a Fellow of the Keith R. Porter Endowment for Cell Biology.

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  1. the National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA

    Eran Meshorer & Tom Misteli

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Meshorer, E., Misteli, T. Chromatin in pluripotent embryonic stem cells and differentiation. Nat Rev Mol Cell Biol 7, 540–546 (2006). https://doi.org/10.1038/nrm1938

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