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The centennial of the Cajal body

Nature Reviews Molecular Cell Biologyvolume 4pages975980 (2003) | Download Citation

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Abstract

Exactly 100 years ago, the Spanish neurobiologist Santiago Ramón y Cajal described a new organelle in the nuclei of vertebrate neurons. Now called the Cajal body, this organelle occurs in many cell types in a wide variety of animals and plants. Recent studies indicate that the Cajal body has numerous roles in the assembly and/or modification of the nuclear-transcription and RNA-processing machinery.

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Acknowledgements

I thank G. Matera for helpful comments. Original studies by J.G.G. that are described here were supported by a grant from the National Institute of General Medical Sciences, USA.

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Affiliations

  1. the Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, 21210, Maryland, USA

    • Joseph G. Gall

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Competing interests

The author declares no competing financial interests.

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DATABASES

LocusLink

SMN1

OMIM

Spinal muscular atrophy

Swiss-Prot

fibrillarin

p80-coilin

SMN

FURTHER INFORMATION

Santiago Ramón y Cajal — Nobel lecture

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DOI

https://doi.org/10.1038/nrm1262

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