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Lateral phosphorylation propagation: an aspect of feedback signalling?

Nature Reviews Molecular Cell Biology volume 4, pages 971–975 (2003)Cite this article

Abstract

Local stimulation with epidermal growth factor can induce lateral propagation of epidermal-growth-factor-receptor phosphorylation at the plasma membrane. We discuss mechanisms of phosphorylation propagation and its possible function. Is it the spatial transmission of a local stimulus or is it an aspect of a feedback-signalling-reaction network that generates a switch response to growth-factor stimulation?

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Figure 1: Spreading of EGFR phosphorylation after local stimulus.
Figure 2: Scenarios for lateral phosphorylation propagation in cells.
Figure 3: Minimal reaction networks regulating receptor phosphorylation.

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Authors and Affiliations

  1. the European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany

    Christian Tischer & Philippe I. H. Bastiaens

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  1. Christian Tischer
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  2. Philippe I. H. Bastiaens
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DATABASES

Swiss-Prot

EGF

EGFR

H-ras

insulin receptor

TrkA

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Tischer, C., Bastiaens, P. Lateral phosphorylation propagation: an aspect of feedback signalling?. Nat Rev Mol Cell Biol 4, 971–975 (2003). https://doi.org/10.1038/nrm1258

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