Dorothy Hodgkin and her contributions to biochemistry

Abstract

The components of cells are molecules — non-living structures that are built up of atoms. It was Dorothy Hodgkin's life's work to determine the three-dimensional structures of many biologically important molecules using the relatively new technique of X-ray diffraction. For this pioneering work, she was awarded the Nobel Prize for Chemistry in 1964.

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Figure 1: Dorothy and Thomas Hodgkin at the Nobel Prize celebration, Stockholm, Sweden, 1964.
Figure 2: Vitamin B12.
Figure 3: Insulin crystals.
Figure 4: The molecular structure of insulin.

References

  1. 1

    Ferry, G. Dorothy Hodgkin: A Life (Granta Books, London, 1998).

    Google Scholar 

  2. 2

    Powell, H. M. & Crowfoot, D. M. Layer-chain structures of thallium di-alkyl halides. Nature 130, 131–132 (1932).

    CAS  Article  Google Scholar 

  3. 3

    Crowfoot, D. & Bernal, J. D. X-ray crystallographic measurements on some derivatives of cardiac aglucones. Chem. Ind. 953–956 (1934).

  4. 4

    Bernal, J. D. & Crowfoot, D. X-ray photographs of crystalline pepsin. Nature 133, 794–795 (1934).

    CAS  Article  Google Scholar 

  5. 5

    Dodson, G. G., Glusker, J. P., Ramaseshan, S. & Venkatesan, K. (eds) The Collected Works of Dorothy Crowfoot Hodgkin Vols 1–3 (Indian Academy of Sciences, Bangalore, 1994).

    Google Scholar 

  6. 6

    Crowfoot, D. X-ray crystallography and sterol structure. Vitam. Horm. 2, 409–461 (1944).

    CAS  Article  Google Scholar 

  7. 7

    Hodgkin, D. C. The X-ray analysis of the structure of pencillin. Adv. Sci. 6, 85–89 (1949).

    CAS  PubMed  Google Scholar 

  8. 8

    Abrahamsson, S., Hodgkin, D. C. & Maslen, E. N. The crystal structure of phenoxymethyl penicillin. Biochem. J. 86, 514–535 (1963).

    CAS  Article  Google Scholar 

  9. 9

    Crowfoot, D., Bunn, C. W., Roger-Low, B. M. & Turner-Jones, A. in The Chemistry of Pencillins 310–367 (Princeton Univ. Press, Princeton, 1949).

    Google Scholar 

  10. 10

    Hodgkin, D., Porter, M. W. & Spiller, R. C. Crystallographic measurement on the anti-pernicious anaemia factor. Proc. R. Soc. Lond. B126, 609–613 (1950).

    Google Scholar 

  11. 11

    Hodgkin, D. C. The structure of the corrin nucleus from X-ray analysis. Proc. R. Soc. Lond. A288, 294–305 (1965).

    Google Scholar 

  12. 12

    Carlisle, C. H. & Crowfoot, D. The crystal structure of cholesteryl iodide. Proc. R. Soc. Lond. A184, 64–83 (1945).

    Google Scholar 

  13. 13

    Hodgkin, D. C. et al. The structure of vitamin B12: (I) an outline of the crystallographic investigation of vitamin B12 . Proc. R. Soc. Lond. A242, 228–263 (1957).

    Google Scholar 

  14. 14

    Brink, C. et al. X-ray crystallographic evidence of the structure of vitamin B12 . Nature 174, 1169–1171 (1954).

    CAS  Article  Google Scholar 

  15. 15

    Hodgkin, D. C. et al. The crystal structure of the hexacarboxylic acid derived from vitamin B12 and the molecular structure of the vitamin. Nature 176, 325–328 (1955).

    CAS  Article  Google Scholar 

  16. 16

    Hodgkin, D. C. et al. The structure of vitamin B12: (II) the crystal structure of hexacarboxylic acid obtained by the degradation of vitamin B12 . Proc. R. Soc. Lond. A251, 306–352 (1959).

    Google Scholar 

  17. 17

    Crowfoot, D. & Dunitz, J. D. The structure of calciferol. Nature 162, 608–609 (1948).

    CAS  Article  Google Scholar 

  18. 18

    Hodgkin, D. C., Rimmer, B. M., Dunitz, J. D. & Trueblood, K. N. The crystal structure of a calciferol derivative. J. Chem. Soc. 4945–4956 (1963).

  19. 19

    Trueblood, K. N. in Structural Studies on Molecules of Biological Interest (eds Dodson, G. G., Glusker, J. & Sayre, D.) 87–105 (Oxford Univ. Press, Oxford, 1981).

    Google Scholar 

  20. 20

    Eschenmoser, A. J. Studies on the synthesis of corrins. Pure Appl. Chem. 7, 297–315 (1963).

    CAS  Article  Google Scholar 

  21. 21

    Crowfoot, D. X-ray single crystal photographs of insulin. Nature 135, 591–592 (1935).

    CAS  Article  Google Scholar 

  22. 22

    Schlichtkrull, J. Insulin crystals I: the minimum mole-fraction of metal in insulin crystals prepared with Zn2+; Cd2+; Co2+; Ni2+; Cu2+; Mn2+; Fe2+. Acta. Chem. Scand. 10, 1455 (1956).

    CAS  Article  Google Scholar 

  23. 23

    Crowfoot, D. & Riley, D. X-ray measurements on wet insulin crystals. Nature 144, 1011–1012 (1939).

    CAS  Article  Google Scholar 

  24. 24

    Crowfoot, D. & Riley, D. An X-ray study of Palmer's lactoglobulin. Nature 141, 521–522 (1938).

    CAS  Article  Google Scholar 

  25. 25

    Dodson, E., Harding, M. M., Hodgkin, D. C. & Rossman, M. G. The crystal structure of insulin III. Evidence for a 2-fold axis in rhombohedral zinc insulin. J. Mol. Biol. 16, 227–241 (1966).

    CAS  Article  Google Scholar 

  26. 26

    Adams, M. J. et al. Structure of rhombohedral 2 zinc insulin crystals. Nature 224, 491–495 (1969).

    CAS  Article  Google Scholar 

  27. 27

    Dodson, G. Dorothy Mary Crowfoot Hodgkin, OM 1910–1994. Biog. Mem. Fell. R. Soc. 48, 179–219 (2002).

    Article  Google Scholar 

  28. 28

    Baker, E. N. et al. The structure of 2Zn pig insulin crystals of 1.5Å resolution. Phil. Trans. R. Soc. Lond. B B319, 369–456 (1988).

    Article  Google Scholar 

  29. 29

    Hodgkin, D. C. The X-ray analysis of complicated molecules: Nobel lecture. Les Prix Nobel 157–178 (1965).

  30. 30

    Hodgkin, D. C. Chinese work on insulin. Nature 255, 103 (1975).

    Article  Google Scholar 

  31. 31

    Schlichtkrull, J. Insulin Crystals (Munksgaard, Copenhagen, 1958).

    Google Scholar 

  32. 32

    Hodgkin, D. C. Insulin, its chemistry and biochemistry. Proc. R. Soc. Lond. B A338, 251–275 (1974).

    Article  Google Scholar 

  33. 33

    Kendrew, J. C. Myoglobin and the structure of proteins. Science 139, 1259–1266 (1963).

    CAS  Article  Google Scholar 

  34. 34

    Perutz, M. F. et al. Structure of haemoglobin: a three dimensional Fourier synthesis at 5.5 Å resolution, obtained by X-ray analysis. Nature 185, 416–422 (1960).

    CAS  Article  Google Scholar 

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myoglobin

pepsin

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Dorothy Crowfoot Hodgkin – Nobel Lecture

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Howard, J. Dorothy Hodgkin and her contributions to biochemistry. Nat Rev Mol Cell Biol 4, 891–896 (2003). https://doi.org/10.1038/nrm1243

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