Proteomics is now considered to be one of the most important 'post-genome' approaches to help us understand gene function. In fact, several genomics companies have launched large-scale proteomics projects, and have started to annotate the entire human proteome. The 'holistic view' painted by a human proteome project is seductive, but is it realistic?
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I would like to thank M. Glotzer for critically reading and discussing this manuscript with me. I would also like to thank Tommy Beck for helping with the web links.
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Huber, L. Is proteomics heading in the wrong direction?. Nat Rev Mol Cell Biol 4, 74–80 (2003). https://doi.org/10.1038/nrm1007
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