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Is proteomics heading in the wrong direction?

Nature Reviews Molecular Cell Biology volume 4, pages 74–80 (2003)Cite this article

Abstract

Proteomics is now considered to be one of the most important 'post-genome' approaches to help us understand gene function. In fact, several genomics companies have launched large-scale proteomics projects, and have started to annotate the entire human proteome. The 'holistic view' painted by a human proteome project is seductive, but is it realistic?

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Figure 1: Tandem-affinity purification.
Figure 2: Multidimensional protein identification technology.
Figure 3: Isotope-coded affinity tag methodology.

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Acknowledgements

I would like to thank M. Glotzer for critically reading and discussing this manuscript with me. I would also like to thank Tommy Beck for helping with the web links.

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Authors and Affiliations

  1. the Department of Histology and Molecular Cell Biology, Institute of Anatomy and Histology, University of Innsbruck, 6020, Innsbruck, Austria

    Lukas A. Huber

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Isotope-Coded Affinity Tags (ICAT) Methodology — Flash Animation

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Huber, L. Is proteomics heading in the wrong direction?. Nat Rev Mol Cell Biol 4, 74–80 (2003). https://doi.org/10.1038/nrm1007

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