Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Progress in mitochondrial replacement therapies

Abstract

Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Gorman, G. S. et al. Mitochondrial diseases. Nat. Rev. Dis. Primers 2, 16080 (2016).

    Article  Google Scholar 

  2. 2

    Suomalainen, A. & Battersby, B. J. Mitochondrial diseases: the contribution of organelle stress responses to pathology. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/nrm.2017.66 (2017).

    Article  Google Scholar 

  3. 3

    Greenfield, A., Braude, P., Flinter, F. & Lovell-Badge, R. Assisted reproductive technologies to prevent human mitochondrial disease transmission. Nat. Biotechnol. 35, 1059–1068 (2017).

    CAS  Article  Google Scholar 

  4. 4

    Ma, H. et al. Functional human oocytes generated by transfer of polar body genomes. Cell Stem Cell 20, 112–119 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Eyre-Walker, A. Mitochondrial replacement therapy: are mito-nuclear interactions likely to be a problem? Genetics 205, 1365–1372 (2017).

    Article  Google Scholar 

Download references

Acknowledgements

Work in the authors' laboratories is funded by grants from The Wellcome Centre for Mitochondrial Research, Medical Research Council, EU Horizon 2020 and the UK NIHR Biomedical Research Centre awarded to Newcastle upon Tyne NHS Trust.

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Mary Herbert or Doug Turnbull.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Herbert, M., Turnbull, D. Progress in mitochondrial replacement therapies. Nat Rev Mol Cell Biol 19, 71–72 (2018). https://doi.org/10.1038/nrm.2018.3

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing