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Progress in mitochondrial replacement therapies


Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.

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Work in the authors' laboratories is funded by grants from The Wellcome Centre for Mitochondrial Research, Medical Research Council, EU Horizon 2020 and the UK NIHR Biomedical Research Centre awarded to Newcastle upon Tyne NHS Trust.

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Correspondence to Mary Herbert or Doug Turnbull.

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The authors declare no competing financial interests.

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Herbert, M., Turnbull, D. Progress in mitochondrial replacement therapies. Nat Rev Mol Cell Biol 19, 71–72 (2018).

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