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DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

Abstract

Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.

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Figure 1: G-quadruplex structures.
Figure 2: Visualization and mapping of G-quadruplex structures.
Figure 3: Therapeutic opportunities.

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Acknowledgements

The Balasubramanian laboratory is core-funded by Cancer Research UK (C14303/A17197) and further supported by a Cancer Research UK programme grant (C9681/A18618). S.B. is a Wellcome Trust Senior Investigator (099232/Z/12/Z).

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Correspondence to Shankar Balasubramanian.

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Hänsel-Hertsch, R., Di Antonio, M. & Balasubramanian, S. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential. Nat Rev Mol Cell Biol 18, 279–284 (2017). https://doi.org/10.1038/nrm.2017.3

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