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Cell death

BCL-2 proteins feed their own expression

Nature Reviews Molecular Cell Biology volume 18, pages 652–653 (2017)Cite this article

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Apoptosis is tuned by a fine balance between the activity of pro-apoptotic and pro-survival (anti-apoptotic) proteins of the BCL-2 family. Wu et al. now show that the upregulation of pro-survival BCL-2 proteins — a hallmark of many cancers — can be driven by a feedforward loop, whereby pro-survival BCL-2 proteins promote the activity of GLI transcription factors, thereby bolstering their own expression.

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  1. Wu, X. et al. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat. Cell Biol. 19, 1226–1236 (2017)

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  1. Paulina Strzyz
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Czabotar, P. E. et al. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15, 49–63 (2014)

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Strzyz, P. BCL-2 proteins feed their own expression. Nat Rev Mol Cell Biol 18, 652–653 (2017). https://doi.org/10.1038/nrm.2017.106

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