An emerging body of evidence indicates that post-transcriptional gene regulation relies not only on the sequence of mRNAs but also on their folding into intricate secondary structures and on the chemical modifications of the RNA bases. These features, which are highly dynamic and interdependent, exert direct control over the transcriptome and thereby influence many aspects of cell function. Here, we consider how the coupling of RNA modifications and structures shapes RNA–protein interactions at different steps of the gene expression process.
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A.K. is supported by grants from the US National Institutes of Health (R01HL126845), the March of Dimes (5-FY14-112) and the Center for Advanced Study at the University of Illinois, Chicago, USA. T.P. is supported by the US National Institutes of Health (R01GM113194). The authors apologize to those whose work could not be cited owing to space restraints.
The authors declare no competing financial interests.
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Lewis, C., Pan, T. & Kalsotra, A. RNA modifications and structures cooperate to guide RNA–protein interactions. Nat Rev Mol Cell Biol 18, 202–210 (2017). https://doi.org/10.1038/nrm.2016.163
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