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Mapping the 3D genome: Aiming for consilience

Nature Reviews Molecular Cell Biology volume 17, pages 741742 (2016) | Download Citation

Abstract

The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.

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References

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Acknowledgements

The author thanks G. Fudenberg, M. Imakaev, L. Mirny and members of the Dekker laboratory for discussions and sharing insights.

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Affiliations

  1. Howard Hughes Medical Institute, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, Massachusetts 01605-0103, USA.

    • Job Dekker

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Correspondence to Job Dekker.

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DOI

https://doi.org/10.1038/nrm.2016.151

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