Basic experimental stem cell research has opened up the possibility of many diverse clinical applications; however, translation to clinical trials has been restricted to only a few diseases. To broaden this clinical scope, pluripotent stem cell derivatives provide a uniquely scalable source of functional differentiated cells that can potentially repair damaged or diseased tissues to treat a wide spectrum of diseases and injuries. However, gathering sound data on their distribution, longevity, function and mechanisms of action in host tissues is imperative to realizing their clinical benefit. The large-scale availability of treatments involving pluripotent stem cells remains some years away, because of the long and demanding regulatory pathway that is needed to ensure their safety.
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A.T. declares competing financial interests as a Board Director of Stem Cells Inc., California, USA, and Cartherics Pty Ltd., Australia.
- Allogeneic therapies
Transplants using cells or tissues derived from a different person.
- Autologous therapies
Immunologically compatible transplants using the patient's own cells or tissues.
- A9 dopaminergic neurons
Mature dopamine-producing neurons of the midbrain substantia nigra, which are lost in Parkinson disease.
Vascular layer of the eye between the retina and the sclera.
- Cell-mediated immune rejection
Activation of the innate immune system in response to cells recognized as foreign, which can constitute a major barrier to successful organ transplantation and allogeneic cell therapies.
Repetitive, involuntary and purposeless movements.
- Expandable (immortal) in culture
Capable of continuous cell replication and passage in vitro without senescence.
- Graft-versus-host disease
(GVHD). When the immune cells of a foreign transplant attack the recipient's own tissues, causing serious life-threatening loss of organ or tissue function.
- Housekeeping genes
Constitutive genes that are responsible for the maintenance of basic cell function and are normally expressed in all cells.
- Humanized mice
Genetically modified mice with human immune cells that are tolerant to human grafts.
- Immune-competent humans
Humans with natural uncompromised immunity.
- Immune-incompetent mice
Mice that are genetically modified to prevent the development of an adaptive immune system.
An area of tissue death or necrosis caused by lack of local oxygen due to blockage of blood supply.
- Knock-in gene mutants
Cells or organisms with gene and regulatory DNA elements introduced into their genomes to enable expression of an introduced mutant gene.
An oval-shaped area near the centre of the retina of the eye, specialized for high-acuity vision.
Glial cell of the central nervous system (CNS) that is responsible for creating the myelin sheath surrounding the axons of CNS neurons, enabling transmission of electronic impulses.
Light-directed identification and control of individual neurons, in living tissue, that have been genetically modified to express light-sensitive ion channels.
Drug-directed control of individual neurons that have been genetically modified to respond to specific drugs.
Tumours with organ and tissue components that are derivatives of more than one germ layer, typically formed in vivo from pluripotent stem cells.
- Tissue stem cell
Undifferentiated stem cell in a tissue or organ that can self-renew and give rise to the major cell types of that tissue or organ. Tissue stem cells are also referred to as adult stem cells or somatic stem cells.
- Ventricular arrhythmias
Severely abnormal heart rhythms that cause the majority of sudden deaths due to heart problems.
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Trounson, A., DeWitt, N. Pluripotent stem cells progressing to the clinic. Nat Rev Mol Cell Biol 17, 194–200 (2016). https://doi.org/10.1038/nrm.2016.10
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