This month marks the first birthday of Nature Reviews Immunology. We hope that we are achieving our goal of providing the immunology community with accessible and stimulating reviews and up-to-date coverage of hot papers from the primary literature, as well as historical and opinion articles in our Perspective section. Certainly, the feedback from the community has been very encouraging — but we are always open to new ideas, so please do get in touch with us (NatureReviews@nature.com) if you have any suggestions or comments about the journal.

In this issue, you will find articles that focus on basic regulatory mechanisms in immunology. On page 725, Qiutang Li and Inder Verma describe how members of the NF-κB family of transcription factors influence immune responses. The recently described role of peroxisome proliferator-activated receptors (PPARs) in modulating inflammation and immunity is outlined in an article by Raymond Daynes and Dallas Jones on page 748. Although we now know quite a lot about how immune responses are initiated, we know rather less about the resolution of inflammatory responses. On page 787, Toby Lawrence and colleagues describe how endogenous anti-inflammatory mediators provide 'off' signals for such responses. A final article related to the regulatory theme, on page 773, is by Toshiaki Kawakami and Stephen Galli. In this article, they describe new roles for monomeric IgE in regulating mast-cell survival and function.

We hope that you have found the first year of Nature Reviews Immunology stimulating, and that you will continue to do so as we develop the journal and serve the immunology community.