Abstract
This special issue of Nature Reviews Immunology focuses on the types of lymphocyte that blur the traditional boundaries between the innate and adaptive immune systems. The development and functional properties of 'innate-like' B and T cells and natural killer (NK) cells are reviewed and the emerging understanding of newly discovered innate lymphoid cells (ILCs) is considered.
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References
Brennan, P. J., Brigl, M. & Brenner, M. B. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nature Rev. Immunol. 13, 101–117 (2013).
Gold, M. C. & Lewinsohn, D. M. Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nature Rev. Microbiol. 11, 14–19 (2013).
Vantourout, P. & Hayday, A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nature Rev. Immunol. 13, 88–100 (2013).
Cerutti, A., Cols, M. & Puga, I. Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nature Rev. Immunol. 13, 118–132 (2013).
Vivier, E. et al. Innate or adaptive immunity? The example of natural killer cells. Science 331, 44–49 (2011).
Bezman, N. A. et al. Molecular definition of the identity and activation of natural killer cells. Nature Immunol. 13, 1000–1009 (2012).
Parham, P. & Moffett, A. Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution. Nature Rev. Immunol. 13, 133–144 (2013).
Walker, J. A., Barlow, J. L. & McKenzie, A. N. J. Innate lymphoid cells — how did we miss them? Nature Rev. Immunol. 13, 75–87 (2013).
Spits, H. & Cupedo, T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu. Rev. Immunol. 30, 647–675 (2012).
Spits, H. et al. Innate lymphoid cells — a proposal for uniform nomenclature. Nature Rev. Immunol. 13, 145–149 (2013).
Acknowledgements
L.L.L. is an American Cancer Society Professor and is supported by US National Institutes of Health grants AI066897, AI068129 and CA095137.
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Lanier, L. Shades of grey — the blurring view of innate and adaptive immunity. Nat Rev Immunol 13, 73–74 (2013). https://doi.org/10.1038/nri3389
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DOI: https://doi.org/10.1038/nri3389
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