Figure 1: Polymorphisms or mutations in TNFAIP3 and human diseases. | Nature Reviews Immunology

Figure 1: Polymorphisms or mutations in TNFAIP3 and human diseases.

From: A20: linking a complex regulator of ubiquitylation to immunity and human disease

Figure 1

The figure shows a schematic of the TNFAIP3 gene locus, which encodes A20. Exons encoding the amino-terminal OTU domain are shown in orange and exons encoding the carboxy-terminal zinc fingers (ZFs) of A20 are shown in green. The C103, ZF4 and ZF7 motifs are highlighted. Non-coding exons, including AT-rich sequences at the end of exon 9, are shown in brown. Human germline single-nucleotide polymorphisms (SNPs) in the TNFAIP3 locus that are associated with autoimmune and autoinflammatory diseases are indicated (labelled with their reference SNP (rs) numbers)26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46, as are somatic mutations that have been identified in the coding exons of TNFAIP3 in human B cell lymphomas50,51,52,53,54.

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