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Highlights of 10 years of immunology in Nature Reviews Immunology

Nature Reviews Immunology volume 11, pages 693–702 (2011)Cite this article

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Abstract

As Nature Reviews Immunology reaches its 10th anniversary, the authors of one of the top-cited articles from each year take a trip down memory lane. We've asked them to look back on the state of research at the time their Review was published, to consider why the article has had the impact it has and to discuss the future directions of their field. This Viewpoint article provides an interesting snapshot of some of the fundamental advances in immunology over the past 10 years. Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10. The complexities in the development and heterogeneity of macrophages, dendritic cells and T helper cells continue to engage immunologists, as do the immune processes involved in diseases such as atherosclerosis. We look forward to what the next 10 years of immunology research may bring.

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Figure 1: Toll signalling pathways.
Figure 2: Plaque activation, rupture and thrombosis.
Figure 3: Pathways to splenic dendritic cells.
Figure 4: General scheme of T-helper-cell differentiation.
Figure 5: Signals that induce interleukin-10 expression by cells of the innate immune response.

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Authors and Affiliations

  1. Ruslan Medzhitov is at the Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. ruslan.medzhitov@yale.edu,

    Ruslan Medzhitov

  2. Ethan M. Shevach is at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. EShevach@niaid.nih.gov,

    Ethan M. Shevach

  3. Giorgio Trinchieri is at the Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA. trinchig@niaid.nih.gov,

    Giorgio Trinchieri

  4. Andrew L. Mellor and David H. Munn are at the Immunotherapy and Cancer Centers, Georgia Health Sciences University, Augusta, Georgia 30912, USA. amellor@georgiahealth.edu; dmunn@georgiahealth.edu,

    Andrew L. Mellor & David H. Munn

  5. dmunn@georgiahealth.edu,

    Andrew L. Mellor & David H. Munn

  6. Siamon Gordon is at the Sir William Dunn School Of Pathology, University of Oxford, Oxford, UK. siamon.gordon@path.ox.ac.uk,

    Siamon Gordon

  7. Peter Libby is at the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. plibby@rics.bwh.harvard.edu,

    Peter Libby

  8. Department of Medicine, Göran K. Hansson is at the Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, SE-17,176, Sweden.,

    Göran K. Hansson

  9. Ken Shortman is at The Walter and Eliza Hall Institute, Melbourne, Australia. shortman@wehi.edu.au,

    Ken Shortman

  10. Chen Dong is at the Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, Texas 77030, USA. CDong@mdanderson.org,

    Chen Dong

  11. Dmitry Gabrilovich is at the H. Lee Moffitt Cancer Center, Tampa, Florida 33647, USA. Dmitry.Gabrilovich@moffitt.org,

    Dmitry Gabrilovich

  12. Ashleigh Howes and Anne O'Garra are at the Division of Immunoregulation, Leona Gabryšová, MRC National Institute for Medical Research, London, UK. aogarra@nimr.mrc.ac.uk,

    Leona Gabryšová, Ashleigh Howes & Anne O'Garra

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Competing interests

Andrew L. Mellor and David H. Munn are members of the scientific advisory board of NewLink Genetics, Inc. and receive compensation and stock options from this source.

Peter Libby is an unpaid investigator in clinical trials of anti-inflammatory treatment of atherosclerosis.

Göran K. Hansson has patents related to immunotherapy of atherosclerosis.

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FURTHER INFORMATION

Medzhitov, R. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1, 135–145 (2001)

Shevach, E. CD4±CD25± suppressor T cells: more questions than answers. Nature Rev. Immunol. 2, 389–400 (2002)

Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Rev. Immunol. 3, 133–146 (2003)

Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nature Rev. Immunol. 4, 762–774 (2004)

Gordon, S. & Taylor, P. R. Monocyte and macrophage heterogeneity. Nature Rev. Immunol. 5, 953–964 (2005)

Hansson, G. K. & Libby, P. The immune response in atherosclerosis: a double-edged sword. Nature Rev. Immunol. 6, 508–519 (2006)

Shortman, K. & Naik, S. H. Steady-state and inflammatory dendritic-cell development. Nature Rev. Immunol. 7, 19–30 (2007)

Dong, C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nature Rev. Immunol. 8, 337–348 (2008)

Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nature Rev. Immunol. 9, 162–174 (2009)

Saraiva, M. & O'Garra, A. The regulation of IL-10 production by immune cells. Nature Rev. Immunol. 10, 170–181 (2010).

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Medzhitov, R., Shevach, E., Trinchieri, G. et al. Highlights of 10 years of immunology in Nature Reviews Immunology. Nat Rev Immunol 11, 693–702 (2011). https://doi.org/10.1038/nri3063

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