Figure 1: Mechanism of NLRP3 inflammasome complex formation. | Nature Reviews Immunology

Figure 1: Mechanism of NLRP3 inflammasome complex formation.

From: NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Figure 1

Under healthy cellular conditions, NLR family, pyrin domain-containing 3 (NLRP3) is auto-repressed owing to an internal interaction between the NACHT domain and LRRs. This auto-repression is removed in the presence of pathogen-associated molecular patterns (PAMPs) from microorganisms or damage-associated molecular patterns (DAMPs) from endogenous danger signals. This results in exposure of the NACHT domain. In turn, NLRP3 oligomerizes and recruits apoptosis-associated speck-like protein containing a CARD (ASC; also known as PYCARD) and pro-caspase 1, triggering the activation of caspase 1 and the maturation and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18. Other cytoplasmic proteins, such as enzymes of the glycolytic pathway, are also substrates of active caspase 1. CARD, caspase-recruitment domain; LRRs, leucine-rich repeats; NACHT, NAIP, CIITA, HET-E and TP1; PYD, pyrin domain.

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