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Multifunctional roles for MALT1 in T-cell activation

Abstract

The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways.

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Figure 1: Roles of MALT1 in receptor-induced NF-κB activation.
Figure 2: Structural and functional elements of MALT1.
Figure 3: Role of MALT1 in TCR-induced signalling pathways.

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Acknowledgements

I would like to thank members of my laboratory for critical comments on the manuscript. Our work is supported by grants from the Swiss National Science Foundation, the Swiss Cancer League and the Novartis and Vontobel Foundations.

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Thome, M. Multifunctional roles for MALT1 in T-cell activation. Nat Rev Immunol 8, 495–500 (2008). https://doi.org/10.1038/nri2338

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