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This study presents a formal demonstration that mature donor T cells induce GVHD.
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This study provides the molecular identification of the first human miHA.
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References 30 and 31 show immunodominance in T-cell responses to miHAs.
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References 32 and 33 demonstrate immunodominance in GVHD.
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This study establishes a mechanism for immunodominance.
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This paper shows that T cells that recognize a single miHA can mediate GVL without causing GVHD. References 35–38 show that GVHD is not easily inducible across a single miHA.
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References 38–41 establish that the identity of specific miHAs can predict for GVHD and/or GVL in human allogeneic haematopoietic SCT.
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This paper establishes that the identity of immunodominant antigens can dictate the phenotype of GVHD.
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This study shows that alloreactive NK cells can mediate a potent GVL effect and can suppress GVHD by eliminating recipient APCs.
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This study shows that CD4+ T cells can mediate GVHD in MHC-mismatched transplants without contacting recipient non-haematopoietic tissues.
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References 50 and 51 establish that radiation-resistant recipient APCs are necessary and sufficient for CD8+ T-cell-mediated GVHD induced in response to miHAs only; nonetheless, donor APCs are required for maximal GVHD.
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References 53–55 establish that effector memory T cells have a reduced capacity to induce GVHD.
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This paper establishes that recipient Langerhans cells that survive conditioning are sufficient to induce GVHD. This has implications for GVHD induced by donor leukocyte infusions.
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References 60–65 are classic studies on the roles of CD4+ and CD8+ T cells in GVHD.
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References 85 and 86 describe the roles of perforin and CD95L in GVHD induced in response to miHAs only.
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This is a comprehensive review on leukocyte migration in GVHD.
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References 114–116 initially established that donor TReg cells suppress GVHD.
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