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Two sides of a cellular coin: CD4+CD3− cells regulate memory responses and lymph-node organization

Nature Reviews Immunology volume 5, pages 655–660 (2005)Cite this article

Abstract

We propose that CD4+CD3− cells have two functions: a well-established role in organizing lymphoid tissue during development, and a newly discovered role in supporting T-cell help for B cells both during affinity maturation in germinal centres and for memory antibody responses. As CD4+CD3− cells express the HIV co-receptors CD4 and CXC-chemokine receptor 4, we think that infection of these cells by HIV, and their subsequent destruction by the host immune system, could help to explain the loss of memory antibody responses and the destruction of lymphoid architecture that occur during disease progression to AIDS.

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Figure 1: Location of adult CD4+CD3−CD11c−B220− cells.
Figure 2: CD4+CD3− cells foster the survival of follicular T cells in germinal centres.
Figure 3: CD4+CD3− cells foster the survival of memory T cells at the B–T interface.

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Acknowledgements

This work was supported by the Wellcome Trust (United Kingdom). We thank I. MacLennan, F. McConnell and G. Anderson for reading the manuscript and providing many helpful comments. We also thank C. Raykundalia, who organized us and made sure that everything in the laboratory worked.

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Authors and Affiliations

  1. the Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Vincent Drive, Birmingham, B15 2TT, UK

    Peter J. L. Lane, Fabrina M. C. Gaspal & Mi-Yeon Kim

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  1. Peter J. L. Lane
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  2. Fabrina M. C. Gaspal
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  3. Mi-Yeon Kim
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Correspondence to Peter J. L. Lane.

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DATABASES

Entrez Gene

CCR7

CD4

CD30

CD30L

CD40

CD80

CD86

CXCR4

ID2

IL-4

IL-7

IL-7R

LT-α

LT-β

LT-βR

OX40

OX40L

TRAF1

TRAF2

TRAF3

TRAF5

TRANCE

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Lane, P., Gaspal, F. & Kim, MY. Two sides of a cellular coin: CD4+CD3− cells regulate memory responses and lymph-node organization. Nat Rev Immunol 5, 655–660 (2005). https://doi.org/10.1038/nri1665

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