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Cancer immunotherapy in 2017

The breakthrough of the microbiota

Nature Reviews Immunology volume 18, pages 8788 (2018) | Download Citation

In 2017, epidemiological studies in humans and experiments in mouse models showed that the intestinal microbiota determines the effectiveness of anticancer immunotherapies. As such the microbiota offers new prognostic biomarkers and shows promise as a target for future antineoplastic treatments.

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Acknowledgements

The authors are supported by grants from the Institut National contre le Cancer, Ligue Nationale contre le Cancer, Swiss Bridge Foundation, ISREC, RHU-TORINO-LUMIERE, SIRIC Socrates at Gustave Roussy and Seerave Foundation.

Author information

Affiliations

  1. Guido Kroemer is at Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers; Paris, France; Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus; Villejuif, France; INSERM U1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité; Paris, France; Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; and Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

    • Guido Kroemer
  2. Laurence Zitvogel is at INSERM U1015, labellisée Ligue Française Contre le Cancer, Université Paris-Saclay, Gustave Roussy Immuno-Oncology Programme, Paris, France.

    • Laurence Zitvogel

Authors

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Competing interests

G.K and L.Z. are co-founders of everImmune, a biotech company that identifies bacteria for cancer treatment.

Corresponding authors

Correspondence to Guido Kroemer or Laurence Zitvogel.

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DOI

https://doi.org/10.1038/nri.2018.4

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