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Gut microbiota

Beyond metagenomics, metatranscriptomics illuminates microbiome functionality in IBD

Nature Reviews Gastroenterology & Hepatology volume 15, pages 193–194 (2018)Cite this article

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Although metagenomic sequencing has provided unprecedented characterization of the gut microbiome, it gives only indirect evidence of the genes and pathways that might be active. Now, investigators have combined longitudinal sampling with metatranscriptomics and metagenomics in IBD to provide a high-resolution picture of the microbiome's functional dynamics.

Refers to Schirmer, M. et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat. Microbiol. https://doi.org/10.1038/s41564-017-0089-z (2018).

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Figure 1: Schematic representation of different views of the gut microbiome.

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Affiliations

  1. Department of Medicine, APC Microbiome Institute, University College Cork, Cork, Ireland

    Aonghus Lavelle

  2. Sorbonne Université, École normale supérieure, PSL Research University, CNRS, INSERM, AP-HP, Hôpital Saint-Antoine, Laboratoire de biomolécules, LBM, Paris, France

    Harry Sokol

  3. INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France

    Harry Sokol

Authors
  1. Aonghus Lavelle
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  2. Harry Sokol
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Correspondence to Harry Sokol.

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Competing interests

H.S. is co-founder of Nextbiotix and has served as consultant for BiomX, Danone, Enterome and Maat pharma. A.L. declares no competing interests.

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Lavelle, A., Sokol, H. Beyond metagenomics, metatranscriptomics illuminates microbiome functionality in IBD. Nat Rev Gastroenterol Hepatol 15, 193–194 (2018). https://doi.org/10.1038/nrgastro.2018.15

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  • DOI: https://doi.org/10.1038/nrgastro.2018.15

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