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NAFLD

PNPLA3 and obesity: a synergistic relationship in NAFLD

Nature Reviews Gastroenterology & Hepatology volume 14, pages 506–507 (2017)Cite this article

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NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.

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Figure 1: Interaction between PNPLA3 genotype and BMI influences the severity of NAFLD.

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Acknowledgements

Q.M.A. is a member of the EPoS (Elucidating Pathways of Steatohepatitis) consortium, which is funded by the Horizon 2020 Framework Program of the European Union under Grant Agreement 634413.

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Authors and Affiliations

  1. UK; and at the Department of Paediatrics, Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, University of Cambridge, Box 116, Level 8, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.,

    Jake P. Mann

  2. and at the Department of Paediatrics, University of Cambridge, Box 116, Level 8, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.,

    Jake P. Mann

  3. Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, 4th Floor, William Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK,

    Quentin M. Anstee

  4. at the Liver Unit, Newcastle Upon Tyne Hospitals NHS Trust, Freeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne NE7 7DN, UK.,

    Quentin M. Anstee

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  1. Jake P. Mann
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Correspondence to Quentin M. Anstee.

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Mann, J., Anstee, Q. PNPLA3 and obesity: a synergistic relationship in NAFLD. Nat Rev Gastroenterol Hepatol 14, 506–507 (2017). https://doi.org/10.1038/nrgastro.2017.74

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