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Viral hepatitis

The bumpy road to animal models for HBV infection

Cell culture infection models help to develop antiviral agents, but animal models are required to understand complex virus–host interactions and the development of immune therapies. Although identification of the HBV uptake receptor enabled establishing cell lines that replicate HBV from its natural transcription template, animal models supporting the full HBV life cycle are still lacking.

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U.P. receives funding from the Institute for Advanced Study at Technische Universität München, Germany, supported via the German Excellence Initiative and EU 7th Framework Programme under grant agreement number 291763. Research in the Protzer laboratory is funded by the German Research Foundation through the collaborative research centres TRR36 and TRR179 and by individual grant PR 618/7, by EU H2020 grant Hep-CAR, by the German Center for Infection Research and by the Helmholtz Validation Fund.

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Correspondence to Ulrike Protzer.

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Protzer, U. The bumpy road to animal models for HBV infection. Nat Rev Gastroenterol Hepatol 14, 327–328 (2017).

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