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Gut microbiota

Neonatal gut microbiota induces lung immunity against pneumonia

Nature Reviews Gastroenterology & Hepatology volume 14, pages 263–264 (2017)Cite this article

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Disruption of the microbiota during early life can have important consequences for infant health outcomes; in particular, antibiotic usage is linked to an increased risk of pneumonia. A new study has identified cellular and molecular mediators involved in the crosstalk between early-life gut bacterial colonization and development of lung immunity against pneumonia in newborn mice.

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Figure 1: Intestinal colonization by commensals drives lung immunity defence in newborn mice.

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Acknowledgements

The authors are partially funded by SUCCESS and the Crohn's and Colitis Foundation of America (grant #362048).

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Authors and Affiliations

  1. Department of Genetics & Genomic Sciences, Icahn Institute for Genomics & Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, 10029, New York, USA

    Sabrina Tamburini

  2. Department of Genetics & Genomic Sciences, and the Precision Immunology Institute and Department of Medicine, Division of Clinical Immunology, Icahn Institute for Genomics & Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, 10029, New York, USA

    Jose C. Clemente

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  1. Sabrina Tamburini
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  2. Jose C. Clemente
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Correspondence to Jose C. Clemente.

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The authors declare no competing financial interests.

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Tamburini, S., Clemente, J. Neonatal gut microbiota induces lung immunity against pneumonia. Nat Rev Gastroenterol Hepatol 14, 263–264 (2017). https://doi.org/10.1038/nrgastro.2017.34

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