Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


High FODMAP diet induces LPS-derived intestinal inflammation and visceral hypersensitivity

A diet high in fermentable oligosaccharides, disaccharides, monosaccharides and polyphenols (FODMAPs) can exacerbate symptoms of IBS, but the mechanism of action is unknown. Zhou et al. fed rats a high FODMAP diet (HFD) and observed increases in faecal Gram-negative bacteria and serum lipopolysaccharide (LPS) levels, accompanied by increased intestinal inflammation, barrier dysfunction and visceral hypersensitivity. To test whether HFD-induced increases in LPS mediate the intestinal pathologies, LPS or faecal supernatant from HFD-fed rats was administered to treatment-naive rats. Similar intestinal barrier dysfunction and visceral hypersensitivity effects were seen, which were blocked by an LPS antagonist or by Toll-like receptor 4 knockdown. Furthermore, faecal LPS levels were found to be higher in patients with IBS (n = 6) than in healthy individuals (n = 6), and a low FODMAP diet was found to reduce LPS levels and improve symptoms in those with IBS.


  1. 1

    Zhou, S.-Y. et al. FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction. J. Clin. Invest. (2017)

Download references


Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dickson, I. High FODMAP diet induces LPS-derived intestinal inflammation and visceral hypersensitivity. Nat Rev Gastroenterol Hepatol 15, 68 (2018).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing