Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

NAFLD in 2017

Novel insights into mechanisms of disease progression

Nature Reviews Gastroenterology & Hepatology volume 15, pages 71–72 (2018)Cite this article

Subjects

In 2017, there have been substantial advances in our understanding of the immunological and endocrine mechanisms of disease progression in NAFLD, paving the way for novel therapeutic strategies.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: NAFLD pathogenesis.

References

  1. Younossi, Z. M. et al. Global epidemiology of nonalcoholic fatty liver disease — meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64, 73–84 (2016).

    Article  Google Scholar 

  2. Wong, R. J. et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology 148, 547–555 (2015).

    Article  Google Scholar 

  3. Luedde, T., Kaplowitz, N. & Schwabe, R. F. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology,147 765–783.e4 (2014).

    Article  CAS  Google Scholar 

  4. Guo, L. et al. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J. Clin. Invest. 127, 4449–4461 (2017).

    Article  Google Scholar 

  5. Jiang, J. et al. Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults. Sci. Rep. 6, 36710 (2016).

    Article  CAS  Google Scholar 

  6. Hart, K. M. et al. Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β. Sci. Transl Med. 9, 396 (2017).

    Article  Google Scholar 

  7. Majumdar, A. et al. Hepatic stem cells and transforming growth factor beta in hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 9, 530–538 (2012).

    Article  CAS  Google Scholar 

  8. Llovet, J. M. et al. Sorafenib in advanced hepatocellular carcioma. N. Engl. J. Med, 359, 378–390 (2008).

    Article  CAS  Google Scholar 

  9. Shalapour, S. et al. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551, 340–345 (2017).

    Article  CAS  Google Scholar 

  10. El-Khoueiry, A. B. et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet 389, 2492–2502 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute for Health, Birmingham Biomedical Research Centre and Centre for Liver Research, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK

    Reenam S. Khan & Philip N. Newsome

Authors
  1. Reenam S. Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philip N. Newsome
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philip N. Newsome.

Ethics declarations

Competing interests

P.N.N. has served as a speaker, a consultant and an advisory board member for AbbVie, Boehringer Ingelheim, Gilead, Intercept, Janssen, Novartis, Novo Nordisk, Pharmaxis and Shire, and has received research funding from these organizations on behalf of the University of Birmingham, UK. R.S.K. has received research funding from the National Institute of Health Research.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khan, R., Newsome, P. Novel insights into mechanisms of disease progression. Nat Rev Gastroenterol Hepatol 15, 71–72 (2018). https://doi.org/10.1038/nrgastro.2017.181

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2017.181

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing