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Stem cells in 2017

Digesting recent stem cell advances in the gut

2017 has witnessed major advances in gut stem cell and cancer stem cell research, delivering key insights into their regulation, more defined culture methods and novel stem cell markers that collectively drive us ever closer to breakthroughs for regenerative medicine and cancer treatment in the clinic.

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Figure 1: Cancer stem cell plasticity and stem cell homeostasis in the gut.


  1. Barker, N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat. Rev. Mol. Cell Biol. 15, 19–33 (2014).

    CAS  Article  Google Scholar 

  2. Yan, K. S. et al. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature 545, 238–242 (2017).

    CAS  Article  Google Scholar 

  3. Janda, C. Y. et al. Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature 545, 234–237 (2017).

    CAS  Article  Google Scholar 

  4. Sigal, M. et al. Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature 548, 451–455 (2017).

    CAS  Article  Google Scholar 

  5. Matsuo, J. et al. Identification of stem cells in the epithelium of the stomach corpus and antrum of mice. Gastroenterology 152, 218–231 (2017).

    Article  Google Scholar 

  6. Leushacke, M. et al. Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach. Nat. Cell Biol. 19, 774–786 (2017).

    CAS  Article  Google Scholar 

  7. Rodriguez-Colman, M. J. et al. Interplay between metabolic identities in the intestinal crypt supports stem cell function. Nature 543, 424–427 (2017).

    CAS  Article  Google Scholar 

  8. Gjorevski, N. et al. Designer matrices for intestinal stem cell and organoid culture. Nature 539, 560–564 (2016).

    CAS  Article  Google Scholar 

  9. Shimokawa, M. et al. Visualization and targeting of LGR5+ human colon cancer stem cells. Nature 545, 187–192 (2017).

    CAS  Article  Google Scholar 

  10. de Sousa e Melo, F. et al. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer. Nature 543, 676–680 (2017).

    CAS  Article  Google Scholar 

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N.B. is supported by the Agency for Science, Technology and Research (A*STAR) and National Research Foundation (NRF), Singapore.

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Correspondence to Nick Barker.

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The author declares no competing financial interests.

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Barker, N. Digesting recent stem cell advances in the gut. Nat Rev Gastroenterol Hepatol 15, 78–80 (2018).

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