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Regenerative medicine

Successful in vivo oesophageal regeneration in a human

Dua and colleagues aimed to regenerate the oesophagus and restore swallowing function in a 24-year-old patient with a full-thickness, long-segment defect using tissue engineering techniques. A fully covered, self-expanding metal stent was used as a scaffold, which was covered in extracellular matrix and sprayed with autologous platelet-rich plasma adhesive gel. 4 years after removal of the stent, full-thickness regeneration of the oesophagus was observed.


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    Dua, K. S. et al. In-vivo oesophageal regeneration in a human being by use of a non-biological scaffold and extracellular matrix. Lancet (2016)

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Leake, I. Successful in vivo oesophageal regeneration in a human. Nat Rev Gastroenterol Hepatol 13, 314 (2016).

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