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IBD

Vitamin D and IBD: moving towards clinical trials

A new study reports that low vitamin D levels are associated with increased morbidity and severity of IBD. A number of issues must now be addressed to enable the optimal design of interventional studies to test whether vitamin D supplementation can improve outcomes in this disease.

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Figure 1: Vitamin D maintains gastrointestinal homeostasis.

References

  1. Ananthakrishnan, A. N. Epidemiology and risk factors for IBD. Nat. Rev. Gastroenterol. Hepatol. 12, 205–217 (2015).

    Article  Google Scholar 

  2. Cantorna, M. T. Vitamin D, multiple sclerosis and inflammatory bowel disease. Arch. Biochem. Biophys. 523, 103–106 (2012).

    Article  CAS  Google Scholar 

  3. Kabbani, T. A. et al. Association of vitamin D level with clinical status in inflammatory bowel disease: a 5-year longitudinal study. Am. J. Gastroenterol. http://dx.doi.org/10.1038/ajg.2016.53 (2016).

  4. Raftery, T. & O'Sullivan, M. Optimal vitamin D levels in Crohn's disease: a review. Proc. Nutr. Soc. 74, 56–66 (2015).

    Article  CAS  Google Scholar 

  5. Miheller, P. et al. Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyvitamin D on bone pathology and disease activity in Crohn's disease patients. Inflamm. Bowel Dis. 15, 1656–1662 (2009).

    Article  Google Scholar 

  6. Yang, L. et al. Therapeutic effect of vitamin D supplementation in a pilot study of Crohn's patients. Clin. Translat. Gastroenterol. 4, e33 (2013).

    Article  CAS  Google Scholar 

  7. Jorgensen, S. P. et al. Clinical trial: vitamin D3 treatment in Crohn's disease a randomized double-blind placebo-controlled study. Aliment. Pharmacol. Ther. 32, 377–383 (2010).

    Article  CAS  Google Scholar 

  8. Ooi, J. H., Li, Y., Rogers, C. J. & Cantorna, M. T. Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis. J. Nutr. 143, 1679–1686 (2013).

    Article  CAS  Google Scholar 

  9. Bruce, D., Yu, S., Ooi, J. H. & Cantorna, M. T. Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling. Int. Immunol. 23, 519–528 (2011).

    Article  CAS  Google Scholar 

  10. Chen, J., Waddell, A., Lin, Y. D. & Cantorna, M. T. Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells. Mucosal Immunol. 8, 618–626 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Work in the Cantorna laboratory was supported by the NIH/National Institute of Neurological Disorders and Stroke NS067563 and National Center for Complementary and Alternative Medicine and the Office of Dietary Supplements AT005378.

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Correspondence to Margherita T. Cantorna.

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The author declares no competing financial interests.

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Cantorna, M. Vitamin D and IBD: moving towards clinical trials. Nat Rev Gastroenterol Hepatol 13, 322–323 (2016). https://doi.org/10.1038/nrgastro.2016.72

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