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Viral hepatitis

HCV compartmentalization in HCC: driver, passenger or both?

Nature Reviews Gastroenterology & Hepatology volume 13, pages 254–256 (2016)Cite this article

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Hepatocellular carcinoma is associated with HCV infection but the underlying interplay between virus and tumour remains to be elucidated. Now, Harouaka et al. report that in patients with HCV-related cirrhosis, HCV replication is restricted within liver tissue originating from hepatocellular carcinoma, with an associated increase in the diversity and complexity of the HCV quasispecies.

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Figure 1: HCV compartmentalization in hepatocellular carcinoma.

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  1. Gastroenterology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, 02114, Massachusetts, USA

    Jacinta A. Holmes & Raymond T. Chung

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  1. Jacinta A. Holmes
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  2. Raymond T. Chung
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Correspondence to Raymond T. Chung.

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The authors declare no competing financial interests.

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Holmes, J., Chung, R. HCV compartmentalization in HCC: driver, passenger or both?. Nat Rev Gastroenterol Hepatol 13, 254–256 (2016). https://doi.org/10.1038/nrgastro.2016.46

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