Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cells

HSCT for Crohn's disease: work in progress or a bridge too far?

Haematopoietic stem cell transplantation for refractory Crohn's disease has the potential to halt therapy-resistant inflammation. Hawkey et al. argue that HSCT does not offer sustained benefit based upon their recent study; however, their study was designed using suboptimal end points and patients were not offered post-transplantation Crohn's disease medication.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hawkey, C. J. et al. Autologous hematopoetic stem cell transplantation for refractory Crohn disease: a randomized clinical trial. JAMA 314, 2524–2534 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Duijvestein, M., van den Brink, G. R. & Hommes, D. W. Stem cells as potential novel therapeutic strategy for inflammatory bowel disease. J. Crohns Colitis 2, 99–106 (2008).

    Article  CAS  PubMed  Google Scholar 

  3. Burt, R. K. et al. Risks of immune system treatments. Science 328, 825–826 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Muraro, P. A. et al. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J. Exp. Med. 201, 805–816 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zhang, L. et al. Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-β-producing CD8+ Treg cells are associated with immunological remission of lupus. J. Immunol. 183, 6346–6358 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Burt, R. K. et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up. Blood 116, 6123–6132 (2010).

    Article  CAS  PubMed  Google Scholar 

  7. D'Haens, G. et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet 371, 660–667 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Wolters, F. L. et al. Crohn's disease: increased mortality 10 years after diagnosis in a Europe-wide population based cohort. Gut 55, 510–518 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lichtenstein, G. R. et al. Serious infections and mortality in associations with therapies for Crohn's disease: TREAT registry. Clin. Gastroent. Hepatol. 4, 621–630 (2006).

    Article  CAS  Google Scholar 

  10. Farge, D. et al. Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group For Blood And Marrow Transplantation Working Party On Autoimmune Diseases. Haematologica 95, 284–292 (2010).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniel W. Hommes.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hommes, D., Lacey, P. HSCT for Crohn's disease: work in progress or a bridge too far?. Nat Rev Gastroenterol Hepatol 13, 128–130 (2016). https://doi.org/10.1038/nrgastro.2016.22

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2016.22

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing